A once-weekly GLP-1 injection clinically proven to help patients lose up to 15% of their body weight in clinical trials. Individual results may vary.
From $166/month
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*Prescription required. Not all patients qualify. This is a compounded medication prepared by a licensed 503A pharmacy and is not an FDA-approved product.
Semaglutide is a GLP-1 receptor agonist that mimics a natural hormone your body produces after eating. It works on multiple pathways to support sustainable weight loss:
Semaglutide acts on the appetite centers in your brain, helping you feel satisfied with less food and reducing cravings throughout the day.
By slowing gastric emptying, semaglutide helps you feel fuller for longer after meals, naturally reducing your caloric intake.
Semaglutide helps stabilize blood sugar levels, reducing energy crashes and the urge to snack between meals.
Many patients report a significant reduction in constant thoughts about food, making it easier to focus on daily life without distraction.
Your weight loss journey with semaglutide injections follows a gradual dosing schedule designed to maximize results while minimizing side effects.
You'll begin with a low dose to allow your body to adjust. Most patients notice a decrease in appetite and reduced cravings within the first week or two.
Your dose is gradually increased. Consistent weight loss begins, some patients may lose approximately 3-5 lbs per month, though individual results vary. Energy levels improve and eating habits shift naturally.
You reach your maintenance dose. Weight loss may accelerate, with some patients in clinical trials seeing 10-15% total body weight reduction. Individual results vary.
Continued weight loss toward your goal. The STEP 1 clinical trial showed patients lost an average of 14.9% of their body weight over 68 weeks. Individual results may vary.
Like all medications, semaglutide may cause side effects. Most are mild to moderate and tend to improve as your body adjusts, especially during the dose escalation period.
Common side effects include:
Less common but serious side effects (contact your provider immediately):
Important Safety Information: Semaglutide may cause thyroid C-cell tumors. It is not known whether semaglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Semaglutide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Always discuss your full medical history with your provider.
Every DirectGLP semaglutide plan comes with everything you need for a successful weight loss journey.
Semaglutide is a GLP-1 receptor agonist - a class of medications originally developed for type 2 diabetes that has been shown to produce significant weight loss. This is a compounded medication prepared by a licensed 503A pharmacy and is not an FDA-approved product.
Semaglutide is injected once weekly using a small needle, typically in the abdomen, thigh, or upper arm. The injection is subcutaneous (just under the skin) and most patients describe it as nearly painless. Your provider will guide you through the process and all supplies are included.
In the STEP 1 clinical trial published in the New England Journal of Medicine, patients using semaglutide 2.4 mg once weekly lost an average of 14.9% of their body weight over 68 weeks, with over 50% of participants achieving at least 15% weight loss. Results vary by individual based on factors like starting weight, diet, exercise, and adherence to the treatment plan.
Most patients begin to notice appetite changes within the first 1-2 weeks. Measurable weight loss typically begins within 4-12 weeks as your dose is gradually increased to the therapeutic level. Individual results may vary.
Yes. Semaglutide is a prescription medication. When you complete our online assessment, a licensed healthcare provider will review your health information and determine if semaglutide is appropriate for you. There is no guarantee of a prescription.
Yes. There are no long-term contracts or commitments. You can pause or cancel your plan at any time with full control over your treatment.
Take our quick assessment to see if semaglutide injections are right for you.
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